Endocrine Abstracts

Thyroid hormone (TH) and TH receptors (TRs) α and β are currently perceived as prototypical nuclear receptors, acting by binding to TH response elements (TREs) in regulatory regions of target genes. This nuclear signaling is long established as the canonical pathway for TH action. However, TRs can also act non-canonically, independent from DNA binding and outside the nucleus, by modulating second messenger signaling in vitro. Whether such non-canonical TR ac...

Thyroid hormone (TH) and TH receptors (TRs) α and β are currently perceived as prototypical nuclear receptors, acting by binding to TH response elements (TREs) in regulatory regions of target genes. This nuclear signaling is long established as the canonical pathway for TH action. However, TRs can also act non-canonically, independent from DNA binding and outside the nucleus, by modulating second messenger signaling in vitro. Whether such non-canonical TR ac...

Thyroid hormone (TH) and TH receptors (TRs) α and β act by binding to TH response elements (TREs) in regulatory regions of target genes. This nuclear signaling is established as the canonical or type 1 pathway for TH action. Nevertheless, TRs also rapidly activate intracellular second-messenger signaling pathways independently of gene expression (noncanonical or type 3 TR signaling). To test the physiological relevance of noncanonical TR signaling, we generated knock...

Introduction: Thyroxine-binding globulin (TBG) is the main thyroid hormone transport protein in blood. So far, 26 TBG deficiency mutations have been reported, 7 of them leading to partial TBG deficiency. We examined T4 binding capacity and the TBG gene in patients with normal free T4 (fT4) and reduced total T4 (TT4). We present and characterize five new partial TBG deficiency mutations.Methods: Automated chemiluminescence immunoassays were used for the d...